Axon regeneration in response to nervous system injury

Axon regeneration in response to nervous system injury


I’m Alex Byrne and I’m an assistant
professor in the Department of Neurobiology I started out being really
interested in genetics with different genetics class in undergrad and that led
me to pursue a graduate degree at the University of Toronto where I studied
genetics again and at the end of my graduate degree I saw a talk on axon
regeneration so it was amazing to me that you could use this tiny worm to
understand how to influence the nervous system to regrow after injury and so we’re looking for genes that
control how an axon can regrow after it’s been injured and so to do that we
study the genetics of this time you little worm called C elegans the beauty
of the system that it has a conserved genome so most of its genes are the same
as ours it also has a really well characterized nervous system and it’s
transparent and so that means that we can take these little worms put them on
a microscope shoot a laser at them to cut one individual neuron and then
manipulate their genome all in a live animal to see how we can get an axon to
regrow or why is it that a maximum doesn’t the ultimate goal of the lab is to not
only understand how the nervous system response to injury but we hope that in
characterizing that process what we find may help develop future strategies for
repair and be injured or the disease nervous system so for example some of
the spinal cord injury or any kind of nervous system disease

Hip Sports Injury | Jaclyn’s Story


Jaclyn:
I ran my first marathon when I was 17 years old. Ever since then,
I was kind of bitten by the distance running bug. About a couple of years ago,
I went for an “easy” 12-mile run and noticed that after the run,
my hip, my right hip, just didn’t feel normal. The pain was so real
that it got to the point that my boyfriend
had to drive me to work because I no longer could walk
a couple blocks to work. So, I went to Penn because I know
how strong they are and how much they really do care
about their patients. – At Penn Medicine,
we’ve developed the Penn Center for the Female Athlete
which is the only truly multidisciplinary center in the region, and it’s one of the few
in the entire country dedicated to the unique needs
of the female athlete. Jaclyn came to us
as a second opinion after having been in pain
for about a year. She had a tear
in the anterior portion of her acetabular labrum. She had worked very diligently with a physical therapist at Penn Medicine. So, while she gained
a lot of core strength and improved her biomechanics, her pain
was still limiting her in terms of
her return to running. We decided that the next best
course of action would be to have a surgical
consultation with Dr. Kamath. – She was an excellent candidate
for the surgery based on the nature
of the severity of the injury but also that she had
really exhausted a lot of the traditional
nonsurgical options that we offer
as a comprehensive approach to treating patients
with hip pain. Surgery went just as planned. We were able to achieve
the repair of the labrum as well as decrease the areas
of impingement within the hip. So, she went through it
with flying colors. Jaclyn:
I’m competitive by nature. I’m going to fight hard
for anything that’s worth fighting for, but the thing is, my doctors
and my therapists at Penn fought right alongside of me. So, we were a team. I didn’t even realize
how limiting the pain was until now that I’m able to
do so much more than I used to be able to do. I just knew in my gut
this is the right thing for me, and I haven’t looked back since.

Ade Edmondson’s cervical fracture – Would I Lie to You? [HD][CC]

Ade Edmondson’s cervical fracture – Would I Lie to You? [HD][CC]


“When I broke my neck at school all
I was given was an aspirin.” – David’s team.
– What happened? How did you break
your neck? – Erm… – LAUGHTER – Don’t worry, we can lose that
pause in the edit! – LAUGHTER – As a young man I was in the gym
team. – Right.
– At school. We were doing a display for…
Whatever you do… Founder’s Day, something like that
you know. I had to do a somersault over a box. A box? A horse. – Yeah, yeah, a horse box.
– The bit… – One of the…
– It wasn’t that big.
– No, a vault.
– Yes. So I jumped over one of those and was supposed to do a somersault,
but I did one and a half. – And landed on your head. – He’s very clever, isn’t he, that
one? – So what happened then, Ade? You
came crashing to the floor? – There was a very loud noise. – Your neck breaking made a noise? – Yes. Why wouldn’t a neck breaking
make a lot of noise? – That’s a good point.
– Wouldn’t you scream anyway? – But the noise would precede the
scream. – But on the way down, on the way to
hitting your neck, presumably you’d be shouting out
something like, “Ahhh!” – No because actually there’s
sometimes a delay before the pain
actually arrives. – Yeah, but there still might be
alarm as you see the chances of you
saving yourself from your neck
breaking. It’s like people in an aeroplane
that’s crashing, they’re probably screaming and you
don’t go, “Well, you’re fine at the moment.” – LAUGHTER AND APPLAUSE So you’ve hit the ground, you fall
to the floor, what happens then? – I was in a great deal of pain.
– Was there a gym teacher present? – There was. He was Scottish. Jock
Watt, his name was. – LAUGHTER – No, no, no.
– That was his…
– Jock Watt. – You had a teacher called Jock
Watt? So what did Watt do? – One of the first things he did… ..was he put out his cigarette. – LAUGHTER – Erm, no…
– On the head of a nearby child. – LAUGHTER – Watt was there…
– Where? – In the display.
– Watt was in the display? What? Part of it? – We’re quite small schoolboys.
– Cheer leaders. – So there’s a kind of teacher to
catch you.
– Oh, yes. – Or half catch you, half catch…
– What, somebody dropped you? – You bounce over the thing and you
sort of… – Is that after he dropped you? Is
that when he went… – LAUGHTER – I was carried off the field of
display. – By what?
– By… – LAUGHTER – And taken to the sick bay… ..where I was given an aspirin. – So where was Watt now? LAUGHTER – I wish his name wasn’t Watt. – Why? LAUGHTER AND APPLAUSE – Oh, dear. – So was it evident to you from the
start that you’d broken your neck? – Er, no. I suffered a great deal of pain for
very many years… ..and didn’t really find out about
the… ..crushed vertebrae… ..until… – Yesterday. – Until a few years after. – So what are you thinking? Are you
thinking that it could be true? – Well, the thing is, I have been
observing him, as I do, and he doesn’t have full movement of
his neck. Look, look at that. – Wow! How long have you been observing him
for, Claude? – Yeah, you see. – What do you think?
– I reckon it’s true now because of the whole neck thing.
– You think it’s true because of inhibited neck movement.
– I do, indeed. – We’re going to say it’s true. – Ade Edmondson, was it true or was
it a lie? – It’s… ..true.
– Yeah! – Yes, it’s true, Ade was given an
aspirin for a broken neck.

ANDRÉ GOMES READS FAN MAIL | MIDFIELDER OPENS LETTERS OF SUPPORT FOLLOWING INJURY


Hey guys. Well… I received a lot of letters and emails
and I would like to thank you all for your kind support. For real, it means a lot to me and it will
make this easier, so thank you very much to all of you. I have one here from Oliver. It says, ‘Dear
André, I hope you get well soon. I can’t wait for you to get back on Goodison Park
and score lots of goals’. Honestly, it’s like a young kid and it means
a lot – especially from a young lad and an Evertonian. From Regan: ‘I’m a Liverpool fan, but I hope
you get better soon’. Thanks a lot. We know how hard it is for a
football fan, especially from another team. It doesn’t matter the colour, so thank you
very much, Regan for your support. I have a few emails as well here… ‘Hi André. I was watching the game against
Spurs at home and I was so disappointed to see you injured that I kicked my table and
broke my toe.’ ‘Best wishes from Ben’. Wow, this is a weird one! Honestly, I feel
bad for you, Ben. I didn’t want that to happen to you. I hope you get well soon. I would
wish that nothing like this would happen to both of us, but thank you very much for your
message and your support. I’m giving best wishes to you as well. A new one… Sharon Richards. It says: ‘You will always have a special place
in our home after treating our Sam to a coat at Everton One last year. You are a brilliant
football player, but what a nice fellow too’. Erm… thank you! Thank you very much. I remember when this happened with Sam. As
I said to all of you before, thank you for your support. A big ‘hi’ to Sam as well. It’s
nice to receive this email from you and thank you – thank you once again. I have a lot of letters here. I will try to
take my time at home with everything. Honestly, guys… It’s almost impossible to put into words.
I feel sensitive and emotional because of what you have done for me. I just need to
thank you all. It’s emotion. I will be back back stronger, for sure. I want to help the team reach the goals we
set at the beginning of the season and once again, thank you. Thank you for everything.

5 Hidden Gems Thriller Movie 2019


Hello everyone, and welcome to my channel. 2019 has been a great year for thriller fans,
John Wick and Knives Out, among others, were highly entertaining. Today we’ll take a look at 5 great titles
that might not be as popular but still have good quality and surprisingly excellent performances. I will try to include variety of choice from
action, mystery and even comedy, Number 5. Hotel Mumbai Based on a true event, Hotel Mumbai is a story
about 2008 terrorist attack on Taj Mahal Palace Hotel. It follows the staffs and guests of the hotel
as they try to survive the grueling attack. There’s always concern on recreating a piece
of history, but Hotel Mumbai is carefully crafted for the suspense while also maintaining
respect for original source. Cinematography takes full advantage of the
gorgeous hotel scenery. This is a survival tale from dusk till dawn
told with great perspective. Lesser movies would use quick editing, but
here Hotel Mumbai knows how to handle its action scenes, and presents the full scope
of the event without being too exaggerated. This means Hotel Mumbai is not going to be
another Die Hard. There’s quite the power dynamic between
the hotel crews and the guests, mainly a couple from England and a shady character from Russia. However, Hotel Mumbai also gives ample time
to the police, bystanders, and even the terrorists themselves. We witness their motivation or how they fare
under pressure, and with good controlled pacing, it never feels overwhelming. While it excels on the technical department,
the human drama makes Hotel Mumbai a compelling watch, and at times even humble and honest. Number 4. Triple Frontier Half action thriller and half heist drama,
Triple Frontier is the more gritty and high-octane movie on the list. Story follows a private military contractor
who comes into information about a rich and cruel drug lord in South America. As it was written in heist movie textbook,
the rogue hero must negotiate with the informant, assemble his misfit crew and eventually tries
to hit the drug lord, lethally and financially. It has quite the star power with Ben Affleck,
Charlie Hunnam and Oscar Isaac signing up for the military oriented team. For a heist movie, it’s quite a straightforward
one, relying more on the action. Fortunately, the characters have more depth
than just ordinary gunslingers. Credit to the actors who bring intensity,
flaws and conflict to the screen with strong performances. A few unorthodox spins to the formula keep
it interesting, and show the chemistry between characters as they are put in one predicament
after another. Triple Frontier is beautifully shot, not many
heist movies are set in jungle or mountain but the cinematography here holds up pretty
well, especially on the second act. The grimy rainy visual adds more to the atmosphere,
and it doesn’t let up when it goes into combat either. Momentum might slow down a bit towards the
end but for those wanting action heist thriller, Triple frontier is a solid watch. Number 3. Daniel Isn’t Real This movie proves that an old fashioned formula
can still be engaging with good execution and performance. The story follows Luke, a young photographer
and student who has an imaginary friend, Daniel. Both the main leads deliver amazing performances. Miles Robbins as Luke captures the dread of
being haunted by mental illness. While Patrick Schwarzenegger, yes, the son
of Arnold, plays the more dominant and often cruel Daniel. The premise may seem familiar, but there’s
enough thrill and twist to elevate the movie into something more than a cliché. There’s clever dialogue and use of psychological
tension to keep you guessing and without spoiling anything it has excellent elements from horror
and mystery as well. I’d even say Daniel Isn’t Real brings
more horror than some of its peers from this year, while still maintaining strong grip
on the psychological aspect. Luke would appear normal at times but we can
see he is slowly consumed by the struggle, the movie takes good care on the theme of
mental trauma. Both the little gestures as sign of anxiety
and the more grandeur horror element are presented with equal excellence. It’s a terrifying and also a contemplating
experience. Number 2. Ready or Not Perhaps the best marriage of comedy and thriller
from this year, Ready or Not is such a fun ride through family feud. Story revolves around Grace who is married
to a rich family. There’s only one catch, she must play a
random game on midnight of the weeding night. The game takes a malicious turn into a survival
game, with Grace as the unwitting participant. Ready or Not is directed in concise and enjoyable
fashion. It jumps from comedic scene to sometimes horror
slasher flick with such ease and delight. The characters are so fun to watch in all
of their dysfunctional glory. These are rich spoiled unpleasant people and
the movie gives all the sweet joy of unbridled revenge thriller. The visual is over the top with every scene
filled with riches and opulence, making more impact as the contrasting carnage hits. It’s funny almost the entire time, yet there’s
a good piece of drama as well. Ready or Not is a festivity, unapologetically
entertaining, unexpectedly gory, and it’s absolutely one of the most fun I’ve had
with thriller from this year. Number 1. Uncut Gems Adam Sandler just came out of nowhere with
Uncut Gems, not only it’s a far cry from his usual comedy antic, but it’s also one
of his best works. There’s a level of energy here other films
just cannot replicate. Story follows Adam Sandler’s character Howard,
a man who runs a jewel store in New York as he lies, gambles and digs himself into increasingly
dangerous situations. Uncut Gems looks like a crime drama thriller
out of the 80s or Grand Theft Auto video games. It’s grimy, loud and it presents New York
bloody dirty secret in back alley dealings and glittering penthouse affair. It’s a crazy ride without any breaks, some
of the scenes are so absurd, like Kevin Garnett using a gem to boost his basketball mojo,
yet these shenanigans are so damn captivating. Cinematography is on a different league, it
conveys so much of the setting. You would feel both uncomfortable and familiar
at the same time as Howard meets with questionable characters, making just as questionable decisions. There are so many subplots and characters
thrown at the screen relentlessly. Most movie would falter on at least one aspect,
but uncut Gems struts with so much confidence you’d believe it cannot fail, and it doesn’t. Uncut Gems is nothing less than a treasure
for thriller genre, it’s a dirty crime thriller in the most glittering captivating spectacle. That’s it for the list, thank you so much
for watching. Please leave a like, comment and subscribe. I make 3 videos every week, have a great and
I’ll see you in the next one.